Technology has advanced. M scale operations are now available, expensive. Therefore only heavily funded scientific M scale labs have the ability to operate within those realms.
Time almost stops, so therefore to build an "outpost" at a p a consecutive and steady stream of Mnauts has to be specced and despecced due to the harsh and unforgiving environment.
With current technology it is only possible to be scaled for 2 hours (real) which gives the Mnaut about 180 hours (interpreted time) at M scale.
The despeccification has to be scheduled, so be ready after the 2\180/ hours. To make sure the work of the Mnaut was not in vain a replacement will have to be ready and continue the work immediately to avoid degeneration of construction, overgrowth or infestation of bears, bacs, zymes.
Tools and arms have a completely different way of working at those scales. So new and quite exotic gadgets have been invented. Most of them are actually still in n scale, where the wielder is required to operate it from M realm.
For the lab workers at the facility it is often very fun to watch the operation log feed which has many posts per minute, sometimes per second even. Since time scale factor is 1/9 at M scale the stationed crew can make decisions and execute tasks way faster than the lab workers at n scale.
Many years later, M scale computers and technology will be produced and used.
Further in the future M terrorism developes. Bears can now be despecced - to cause havoc in our own realm.
